Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions.Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvironment (TME) following immunotherapy treatments is critical to identifying the determinants of therapeutic succ
Introduction.Complete denture reinforced with metal bases is fabricated in cases of fracture risk as well as in selected patients with neuromuscular disorders.The aim of this report was to present different designs of metal framework for complete denture and their advantages in the treatment of edentulous patients.Material and Methods.The study inc
Background: The understanding of the pathogenesis of cytomegalovirus (CMV)-induced fetal brain lesions is limited.We aimed to quantify adaptive and innate immune cells and CMV-infected cells in fetal brains with various degrees of brain damage.Methods: In total, 26 archived embedded fetal brains were studied, of which 21 were CMV-infected and class
Specialized microenvironments called niches regulate tissue homeostasis by controlling the balance between stem cell self-renewal and the differentiation of stem cell daughters.However the mechanisms that govern the formation, size and signaling of in vivo niches remain poorly understood.Loss of the highly conserved histone demethylase Lsd1 in Dros
IntroductionIntracranial hemorrhage is a significant cause of neurological damage in newborns.Extra-axial hemorrhages with intraparenchymal extension can precipitate acute clinical deterioration.Seizures are one of the presenting symptoms, which can be refractory to treatment.These hemorrhages can result in considerable long-term morbidity and mort